Diagnosis, classification, and prognosis of myelodysplastic syndromes

Introduction. Myelodysplastic syndromes represent clonal neoplastic disorders characterized by hematological dysplasia, ineffective hematopoiesis, cytopenia, and increased risk of transformation to acute myeloid leukemia. Material Methods. A literature review was conducted using the following bibliographic databases: Google Scholar, MEDLINE, Kobson. The recommendations for diagnosis, classification, prognosis are based on expert opinions grounded a contemporary diagnosis in myelodysplastic syndrome. Diagnosis classification. syndrome should be detailed patient family history, physical examination, comprehensive blood examinations exclude all other causes cytopenia dysplasia. Mandatory is cytology bone marrow, marrow biopsy with immunohistology cytogenetics. 2016 World Health Organization classification used diagnosis. SF1B3 genetic analysis recommended patients suspected ringed sideroblasts p53 mutation status. Prognosis. Revised International Prognostic Scoring System (IPSS-R) score defined every order determine prognosis. next-generation sequencing could provide additional diagnostic prognostic information, particularly young transplant candidates. Conclusion. possible addition analysis.